morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
GYY 4137 Morpholine salt
CAS: 106740-09-4
Molecular Formula: C15H25N2O3PS2
morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate - Names and Identifiers
morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate - Physico-chemical Properties
| Molecular Formula | C15H25N2O3PS2 |
| Molar Mass | 376.474361 |
| Melting Point | 164-166℃ |
| Appearance | White solid. |
| Storage Condition | 2-8℃ |
| In vitro study | GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38). GYY4137 (0.1-0.5 mM) decreases LPS-induced production of nitrite (NO2−), PGE2, TNF-α and IL-6 from human synoviocytes (HFLS) and articular chondrocytes (HAC), reduces the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-κB activation. Cell Viability Assay Cell Line: HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS Concentration: 400 or 800 µM Incubation Time: 5 days Result: Significantly affected cancer cell survivability. |
| In vivo study | GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner. In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA. GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression. GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease. Animal Model: Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells) Dosage: 100, 200 and 300 mg/kg Administration: I.p.; daily for 14 days Result: Reduced tumor volume by 52.5±9.2% and 55.3±5.7% in HL-60 and MV4–11 injected animals. |
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View History
morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
2-(2-METHYLPHENOXY)PROPIONIC ACID
去芹菜糖基桔梗皂苷D3
2-CHLORO-N-[4-(4-FLUORO-PHENYL)-THIAZOL-2-YL]-PROPIONAMIDE
2-硝基-1-苯基丙烯
3-羟基环丁基甲酸苄酯
PERFLUORO-1-OCTANESULFONYL FLUORIDE
氨基-十二聚乙二醇-羧酸
2-[(6-chloro-3-pyridazinyl)thio]ethanol(SALTDATA: FREE)
2-乙基-5-溴苯甲酸甲酯
2-(2-METHYLPHENOXY)PROPIONIC ACID
去芹菜糖基桔梗皂苷D3
2-CHLORO-N-[4-(4-FLUORO-PHENYL)-THIAZOL-2-YL]-PROPIONAMIDE
2-硝基-1-苯基丙烯
3-羟基环丁基甲酸苄酯
PERFLUORO-1-OCTANESULFONYL FLUORIDE
氨基-十二聚乙二醇-羧酸
2-[(6-chloro-3-pyridazinyl)thio]ethanol(SALTDATA: FREE)
2-乙基-5-溴苯甲酸甲酯